The Dead End Kids go after a gang known as the Sea Raiders, which is sinking Allied shipping.

Mandrake and his assistant Lothar are working the cruise lines and make the acquaintance of Professor Houston who has developed a radium energy machine, which is much coveted by a masked Crime Lord known as "The Wasp".

A gambling ring run out of the Mogul Taxi company is intent on fixing college football games. Football star Harold "Red" Grange is a target for the gamblers, whose thugs try to eliminate Grange from playing. Grange's buddy Buddy is himself vulnerable to blackmail, since he has broken team rules by marrying. The crooks use all their wiles to keep Grange and Buddy from leading their team to victory.

An intrepid reporter and his loyal friend battle a bizarre secret society of criminals known as The Vampires.

A madman sets out to destroy a group of Chinatown merchants.

A crime fighter known as The Spider battles a villain called The Octopus, who is out to sabotage America and install his own government.

The struggle over the Bellamy estate ends with Michael Bellamy accused of murder and killed on the way to prison, while his brother, Abel Bellamy, takes control of the estate for his own nefarious plans.