The period is the 1820's and the first wagon train leaves Independence heading west to Santa Fe. In order to maintain his power, the ruthless Official at Santa Fe must not let them arrive and he sends out his men to stop them. The wagon train then has to endure repeated attacks but is aided by a mysterious rider that shoots singing arrows and rides a painted stallion.
Strategic targets on Earth are being destroyed by an unknown weapon. Government security head Henderson suspects it's an "atomic ray" originating from the moon! He assigns Commando Cody, scientist and man of action with a secret flying suit, to investigate. Soon, Cody is battling Earth thugs in the pay of Krog the moon man and making trips in his experimental rocket to the moon itself, in a perilous and all but singlehanded effort to thwart the planned invasion of Earth.
Young Pauline is left a lot of money when her wealthy uncle dies. However, her uncle's secretary has been named as her guardian until she marries, at which time she will officially take possession of her inheritance. Meanwhile, her "guardian" and his confederates constantly come up with schemes to get rid of Pauline so that he can get his hands on the money himself.