Produced at the same time as the more well-known The Twilight Zone (1959), this series was an extension of the tradition of radio horror and supernatural dramas such as Light's Out, The Mysterious Traveler and The Witches Tale. As with the Twilight Zone and the radio programs each tale was book-ended by an introduction and conclusion by a host. However, rather than creating fictional stories with supernatural twists and turns, this program sought out "real" stories of the supernatural, including ghosts, disappearances, monsters and the like, re-creating them for each episode. No solutions to these mysteries were ever found, and viewers could only scratch their heads and wonder, "what if it's real?"

A master criminal called The Spider puts the famous detective's brother under a hypnotic spell and turns him against Dick.

A western adventure serial in 12 episodes. Buffalo Bill battles gambler Jim Rodney who is trying to scare off the townspeople so he can gain possession of a gold strike discovered in the area. A nearby Indian tribe is provoked to attack the town and the cavalry is called in.

Young Pauline is left a lot of money when her wealthy uncle dies. However, her uncle's secretary has been named as her guardian until she marries, at which time she will officially take possession of her inheritance. Meanwhile, her "guardian" and his confederates constantly come up with schemes to get rid of Pauline so that he can get his hands on the money himself.

A stage and a wagon heading west get separated from the rest of the wagon train thanks to Dusty. Now they must make their way to California.

A mad scientist tries to sell his formula for a dist integrating gas to foreign powers.