A crime fighter known as The Spider battles a villain called The Octopus, who is out to sabotage America and install his own government.

New York City policewoman Casey Jones' assignment to fight crime often entails her going undercover in some of the seediest and most dangerous parts of the city.

The Eagle uses sky writing to make threats against a corporation. Nathan Gregory owns a traveling fairground and is thought to be the Eagle. Craig McCoy is a pilot who goes looking for the Eagle when Gregory turns up missing.

Highlights the personal and professional lives of a group of doctors and surgeons headed by Dr. Konrad Styner. One of the first medical shows on TV that paid strict attention to detail, and heralded at the time for its sometimes unflinching look at the operations and medical procedures performed by doctors.

A murderous gang of counterfeiters has kidnapped the government's best engraver and is forcing him to print virtually undetectable phony money. The Secret Service sends its toughest agent, Jack Holt, and a female partner after the gang.

Tom Wayne rescues Clancy, Renard and Schmidt in the Arabian desert and they join him in going after El Shaitan, a bad guy who is never seen as he tries to wipe out the Foreign Legion.

Beyond Hell's Gate Pass is territory controlled by a man who calls himself King Carter; he uses a variety of schemes to prevent the railroad from being built, for fear it will finish his control of (what he considers) his land.

Professor Davidson and his niece Diana Palmer search Africa for the Lost City of Zoloz, reputed to be the source of a large hidden treasure. Also searching is a local crook, Singapore Smith, and Dr. Max Bremmer, who plans to destroy the peace in which the native tribes have been living. However, Godfrey Prescott, otherwise known as the Phantom, is feared and respected by the natives and is able to circumvent the traps and schemes of the villains.

Captain Dan Tempest was an ex-pirate who received a pardon from the King and turned privateer after his stronghold of New Providence was taken over by Crown soldiers. Tempest and Lt. Beamish, the Crown-appointed deputy governor, were uneasy allies, fighting the Spanish privateers who were ravaging the Caribbean.