Flash Gordon, Dale Arden and Dr. Zarkov return to the planet Mongo for an antidote to the Purple Death, which wreaking destruction on Earth. However, Ming the Merciless has other plans for them.

A young couple journeys to Mystery Island to rescue the girl's father, who is being held prisoner by the evil Captain Mephisto, a pirate from 200 years ago who uses his Transformation Machine to travel forward in time and disguise himself as one of the four owners of Mystery Island.

When the ancient continent of Mu sank beneath the ocean, some of its inhabitant survived in caverns beneath the sea. Cowboy singer Gene Autry stumbles upon the civilization, now buried beneath his own Radio Ranch. The Muranians have developed technology and weaponry such as television and ray guns. Their rich supply of radium draws unscrupulous speculators from the surface. The peaceful civilization of the Muranians is corrupted by the greed from above, and it becomes Autry's task to prevent all-out war, ideally without disrupting his regular radio show.

Animal trainer Clyde Beatty heads a rescue party in search of his girl, Ruth, and her father who get lost looking for an uncharted island. His dirigible crashes into the jungles of the island. When he locates Ruth, he learns that her father has disappeared. The ensuing search is hindered by greedy gold hunters and wild animals.

Strategic targets on Earth are being destroyed by an unknown weapon. Government security head Henderson suspects it's an "atomic ray" originating from the moon! He assigns Commando Cody, scientist and man of action with a secret flying suit, to investigate. Soon, Cody is battling Earth thugs in the pay of Krog the moon man and making trips in his experimental rocket to the moon itself, in a perilous and all but singlehanded effort to thwart the planned invasion of Earth.

Superhero Captain America battles the evil forces of the archvillain called The Scarab, who poisons his enemies and steals a secret device capable of destroying buildings by sound vibrations.