Mandrake and his assistant Lothar are working the cruise lines and make the acquaintance of Professor Houston who has developed a radium energy machine, which is much coveted by a masked Crime Lord known as "The Wasp".

Highlights the personal and professional lives of a group of doctors and surgeons headed by Dr. Konrad Styner. One of the first medical shows on TV that paid strict attention to detail, and heralded at the time for its sometimes unflinching look at the operations and medical procedures performed by doctors.

Jerry and Pamela North live in Greenwich Village in New York City. Jerry is a mystery magazine publisher who thinks he is a good amateur detective. He and his wife investigate various crimes and solve them before the police do.

Former combat cameraman Mike Kovac is now a freelance photographer in New York City, specializing in difficult and dangerous assignments where he can get the kinds of pictures that other photographers can't, or won't take. He sometimes gets help, often reluctantly, from his contact in the police department, Lt. Donovan, and advice from his immigrant father Anton.

Saloon owner Barnet wants the Indian reservation land on which he knows there is gold, and organizes a gang, aided by some renegade Indians, to raid and terrorize close-by settlers,hoping to arouse them to drive off the Indians. Rancher Jerry Randall, accompanied by school teacher Nancy Cooper, sets out to defeat the plot. In order to win the loyalty of the innocent tribe members, Randall masquerades as a legendary friend of the Indians, El Latigo.

A movie serial in 13 chapters: Some swampland becomes valuable, and various factions squabble over ownership of it.

Two investigators for a stagecoach company are assigned to find out why the company's stages keep being ambushed. They discover that the culprits are white men disguised as Indians, and they set out to discover who is behind the plot.

A young couple journeys to Mystery Island to rescue the girl's father, who is being held prisoner by the evil Captain Mephisto, a pirate from 200 years ago who uses his Transformation Machine to travel forward in time and disguise himself as one of the four owners of Mystery Island.

Produced at the same time as the more well-known The Twilight Zone (1959), this series was an extension of the tradition of radio horror and supernatural dramas such as Light's Out, The Mysterious Traveler and The Witches Tale. As with the Twilight Zone and the radio programs each tale was book-ended by an introduction and conclusion by a host. However, rather than creating fictional stories with supernatural twists and turns, this program sought out "real" stories of the supernatural, including ghosts, disappearances, monsters and the like, re-creating them for each episode. No solutions to these mysteries were ever found, and viewers could only scratch their heads and wonder, "what if it's real?"