The period is the 1820's and the first wagon train leaves Independence heading west to Santa Fe. In order to maintain his power, the ruthless Official at Santa Fe must not let them arrive and he sends out his men to stop them. The wagon train then has to endure repeated attacks but is aided by a mysterious rider that shoots singing arrows and rides a painted stallion.

Highlights the personal and professional lives of a group of doctors and surgeons headed by Dr. Konrad Styner. One of the first medical shows on TV that paid strict attention to detail, and heralded at the time for its sometimes unflinching look at the operations and medical procedures performed by doctors.

A newspaper publisher and his Korean servant fight crime as vigilantes who pose as a notorious masked gangster and his aide.

Texas Ranger tries to stop takeover of Indian lands.

Enemy spies try to steal a new fighter plane.

Deadwood Dick, a masked and mysterious hero, is in reality Dick Stanley, editor of the Dakota Pioneer Press and a leading member of Statehood For Dakota. He is on the trail of a masked villain known as the Skull, who leads a violent, renegade band infamous for its violence against the Deadwood residents' wishes for a statehood status.

A young girl journeys to Africa to find her father, an explorer who vanished in the jungle.

An adventurer goes after Nazi spies who have a new death ray called the Paratron.